Study summary
Boron neutron capture therapy dose calculations depend on uncertain tissue boron uptake. This study investigates a two-evaluation dose envelope on the modified Snyder head phantom and compares an independent OpenMC transport model with published reference dosimetry.
All 184 epithermal-beam reference points agree within the declared ±10% tolerance. Across two uncertainty sets, all 22 non-corner evaluations are compatible with the recorded envelopes under the study’s uncertainty-tolerant comparison rule. The full predeclared validation gate was not met.
Conditional absorption monotonicity supports boron and nitrogen component bounds. The total-dose construction also uses photon and fast-component approximations whose continuum-wide coverage is not established. The results support a phantom feasibility study, not certified total-dose bounds or clinical plan acceptance.
Reproducibility
The v1.0.0 package includes Python transport and analysis code, independent numerical checkers, recorded tally summaries, scientific protocols and figure-generation scripts. The 93 numerical consistency checks pass; this does not change the study’s incomplete validation grade. Public access is provided with rights reserved.